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  • DNAJC9 Integrates Heat Shock Molecular Chaperones into the Histone Chaperone Network

    Authors
    Hammond, Colin M.
    Reverón-Gómez, Nazaret
    Groth, Anja
    Description

    Summary from the GEO: "From biosynthesis to assembly into nucleosomes, histones are handed through a cascade of histone chaperones, which shield histones from non-specific interactions. Whether mechanisms exist to safeguard the histone fold during histone chaperone handover events or to release trapped intermediates is unclear. Using structure-guided and functional proteomics, we identify and characterize...

    Subject
    Histone Chaperones
    Histones
    HSP40 Heat-Shock Proteins
    HSP70 Heat-Shock Proteins
    Minichromosome Maintenance Complex Component 2
    Access Rights
    Free to All
  • Crystal structure of DNAJC9 HBD helix2 in complex with H3.3-H4 dimer and MCM2 HBD

    Authors
    Bao, Hongyu
    Huang, Hongda
    Description

    This deposit in the Research Collaboratory for Structural Bioinformatics Protein Data Base (PDB) includes electron microscopy data identifying the crystal structure of DNAJC9 HBD helix2 in complex with H3.3-H4 dimer and MCM2 HBD. The main summary display for this entry includes information on the experimental method, validation, macromolecules and small molecules included in the deposit, as well as...

    Subject
    Histone Chaperones
    Histones
    HSP40 Heat-Shock Proteins
    Minichromosome Maintenance Complex Component 2
    Access Rights
    Free to All
  • Crystal structure of DNAJC9 HBD in complex with H3.3-H4 dimer and MCM2 HBD

    Authors
    Bao, Hongyu
    Huang, Hongda
    Description

    This deposit in the Research Collaboratory for Structural Bioinformatics Protein Data Base (PDB) includes electron microscopy data identifying the crystal structure of DNAJC9 HBD in complex with H3.3-H4 dimer and MCM2 HBD. The main summary display for this entry includes information on the experimental method, validation, macromolecules and small molecules included in the deposit, as well as version...

    Subject
    Histone Chaperones
    Histones
    HSP40 Heat-Shock Proteins
    Minichromosome Maintenance Complex Component 2
    Access Rights
    Free to All
  • Proteomics Data for "DNAJC9 integrates heat shock molecular chaperones into the histone chaperone network"

    Authors
    Hendriks, Ivo
    Nielsen, Michael L.
    Description

    Description from PRIDE: "From biosynthesis to assembly into nucleosomes, histones are handed through a cascade of histone chaperones, which shield histones from non-specific interactions. Whether mechanisms exist to safeguard the histone fold during histone chaperone handover events or to release trapped intermediates is unclear. Using structure-guided and functional proteomics, we identify and characterize...

    Subject
    Histone Chaperones
    Histones
    HSP40 Heat-Shock Proteins
    HSP70 Heat-Shock Proteins
    Minichromosome Maintenance Complex Component 2
    Access Rights
    Free to All
  • DNAJC9 integrates heat shock molecular chaperones into the histone chaperone network. (Hammond et al. 2021)

    Authors
    Hammond, Colin M.
    Bao, Hongyu
    Huang, Hongda
    Groth, Anja
    Description

    Raw data for Western blots, gel-based assays and ITC as a pdf. These images are correlated with the experiments and descriptions of the associated publication. Overall, research for the publication demonstrated that "DNAJC9 integrates ATP-resourced protein folding into the histone supply pathway to resolve aberrant intermediates throughout the dynamic lives of histones."

    Subject
    Chromatin
    Histone Chaperones
    Histones
    HSP40 Heat-Shock Proteins
    Access Rights
    Free to All